Using telomeres to study the DNA damage response
Relevant Publications
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature: ePub ahead of print.
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell 163: 880-893.
M. Zimmermann, and T. de Lange (2013) 53BP1: pro choice in DNA repair. Trends Cell Biol 24: 108-117.
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.
F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA 110: 2146-2151. **equal contribution. *corresponding author.
A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597.
T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.
S. Buonomo, Y. Wu, D. Ferguson, T. de Lange (2009) Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187: 385-398.
N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell. Biol. 290: 5552-5563.
N. Dimitrova, YC. Chen, DL. Spector, T. de Lange (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature.456: 524-528.
P. Wu and T. de Lange (2008) No Overt Nucleosome Eviction at Deprotected Telomeres. Mol. Cell Biol. 28: 5724-5735.
A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes Dev. 22: 1221-1230.
N. Dimitrova and T. de Lange (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes and Development. 20: 3238-3243
J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.
