TRF1 promotes telomere replication and prevents formation of fragile telomeres

Relevant Publications

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T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138: 90-103.

N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465-474

 

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Relevant PublicationsBack to main pageT. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF