TRF1 promotes telomere replication and prevents formation of fragile telomeres
Relevant Publications
T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.
M. Zimmermann, T. Kibe, S. Kabir, T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138: 90-103.
N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465-474