Repression of ATR signaling by POT1

Relevant Publications

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K. Kratz & T. de Lange (2018) Both Protection of Telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion but binding to CST limits ATR repression by POT1b. J Biol Chem: ePub ahead of print

T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397-399.

H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehrani, D.A. Chitayat, Y.J. Crow & T. de Lange (2016) A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes Dev 30: 812-826.

T. Kibe, M. Zimmermann & T. de Lange (2016) TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell 61: 236-246

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

D. Frescas, and T. de Lange (2014) TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1. Mol Cell Biol 34: 1349-1362.

D. Frescas, and T. de Lange (2014) Binding of TPP1 to TIN2 is required for POT1a,b-mediated telomere protection. J Biol Chem 289: 24180-24187.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2009) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29: 471-482.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448: 1068-1071.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8: 754-761.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.

 

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Relevant PublicationsBack to main pageK. Kratz & T. de Lange (2018) Both Protection of Telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion but binding to CST limits