Generation of the 3’ overhang

Relevant Publications

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T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.

H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehrani, D.A. Chitayat, Y.J. Crow & T. de Lange (2016) A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes Dev 30: 812-826.

P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2009) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29: 471-82.

D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.

Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-1096.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8: 754-761.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

M. van Overbeek and T. de Lange (2006) Apollo, an Artemis related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol.16: 1295-1302.

T. de Lange (2005). Shelterin: the protein complex that shapes and safe-guards human telomeres. Genes and Development 19: 2100-2110.

D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.

 

 

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Relevant PublicationsBack to main pageT. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehra