Repression of ATM signaling and NHEJ by TRF2: t-loops

Relevant Publications

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T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrity. Nat. Struct. Mol. Biol.: 24:734-742.

L.A. Timashev, H. Babcock, X. Zhuang & T. de Lange (2017) The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev 31: 578-589.

Y. Doksani & T.  de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep. 17: 1646-1656.

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397-399.

T. de Lange (2015) A loopy view of telomere evolution. Front. Genet. 6:321.

Y. Doksani, and T de Lange (2014)  The role of double-strand break repair pathways at functional and dysfunctional telomeres.  Cold Spring Harb. Perspect. Biol. 2014 6: 1-15.

Y. Doksani*, J.Y. Wu*, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356.  *equal contribution

A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597

T. de Lange (2011) How shelterin solves the telomere end-protection problem. 75th CSH Symp.Quant. Biol., 75:167-177.

T. de Lange (2009) How telomeres solve the end-protection problem. Science 326: 948-952.

N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell. Biol. 290: 5552-5563.

W. Palm and T. de Lange (2008) How shelterin protects mammalian telomeres. Ann Rev Genetics 42: 301-334.

A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes Dev. 22: 1221-1230.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448: 1068-1071.

E. Lazzerini Denchi, G.B. Celli and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.

G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol. 8: 855-862.

T. de Lange (2005). Shelterin: the protein complex that shapes and safe-guards human telomeres. Genes and Development 19: 2100-2110.

G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol. 7: 712-718.

Y. Doksani & T.  de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep. 17: 1646-1656.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.

T. de Lange (2004) T-loops and the origin of telomeres. Nature Rev. Mol. Cell Biol. 5: 323-329.

X.-D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J. H. J. Hoeijmakers, and T. de Lange (2003) ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA containing double minute chromosomes. Mol Cell 6: 1489-1498.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr. Biol. 12: 1634-1644.

R. Stansel, T. de Lange, J. D. Griffith (2001) T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J. 20: 5532-5540.

J. L. Munoz-Jordan, G .A. M. Cross, T. de Lange, and J. D. Griffith. (2001) T-loops at trypanosome telomeres. EMBO J. 20: 579-588.

J. D. Griffith, L. Comeau, S. Rosenfield, R. Stansel, A. Bianchi, H. Moss, T. de Lange. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514.

J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell92: 401-413.

 

 

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Relevant PublicationsBack to main pageT. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (