How shelterin solves the end-protection problem

Relevant Publications

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T. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.

T. De Lange (2018) What I got wrong about shelterin. J. Biol. Chem. 293: 10453-10456.

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrity. Nat. Struct. Mol. Biol.: 24:734-742.

L.A. Timashev, H. Babcock, X. Zhuang & T. de Lange (2017) The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev 31: 578-589.

F. Erdel, K. Kratz, S. Willcox, J.D. Griffith, E.C. Greene & T. de Lange (2017) Telomere Recognition and Assembly Mechanism of Mammalian Shelterin. Cell Rep 18: 41-53.

Y. Doksani & T.  de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep. 17: 1646-1656.

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397-399.

T. Kibe, M. Zimmermann & T. de Lange (2016) TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell 61: 236-246

H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehrani, D.A. Chitayat, Y.J. Crow & T. de Lange (2016) A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes Dev 30: 812-826.

T. de Lange (2015) A loopy view of telomere evolution. Front. Genet. 6: 321.

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

S. Kabir, D. Hockemeyer, T. de Lange (2014). TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Cell Rep 9:1273-1280

Y. Doksani, and T de Lange (2014)  The role of double-strand break repair pathways at functional and dysfunctional telomeres.  Cold Spring Harb. Perspect. Biol. 2014 6: 1-15

D. Frescas, and T. de Lange (2014) Binding of TPP1 to TIN2 is required for POT1a,b-mediated telomere protection. J Biol Chem 289: 24180-24187.

D. Frescas, and T. de Lange (2014) TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1. Mol Cell Biol 34: 1349-1362.

D. Frescas and T. de Lange (2014) A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes Dev. 28: 153-166.

Y. Doksani*, J.Y. Wu*, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356.  *equal contribution

N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465-474.

A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

T. de Lange (2011) How shelterin solves the telomere end-protection problem. 75th CSH Symp.Quant. Biol., 75: 167-177.

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.

de Lange, T. (2010) Telomere Biology and DNA repair: Enemies with benefits. FEBS Letters 584: 3673-3674.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. Chem. 285: 1457-1467.

T. de Lange (2009) How telomeres solve the end-protection problem. Science 326: 948-952.

A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2009) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29: 471-82.

W. Palm and T. de Lange (2008) How shelterin protects mammalian telomeres. Ann Rev Genetics 42:301-334.

A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes Dev. 22: 1221-1230.

Y. Chen, Y. Yang, M. van Overbeek, J. R. Donigian, P. Baciu, T. de Lange, and M. Lei (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-1096.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448:1068-1071.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-761.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

T. de Lange (2005). Shelterin: the protein complex that shapes and safe-guards human telomeres. Genes and Development 19: 2100-2110.

G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol. 7: 712-718.

D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krut chinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279: 47264-47271.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

J. Z.-S. Ye and T. de Lange (2004) TIN2 is a tankyrase 1 PARP-modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623.

D. Loayza, H. Parsons, J. R. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem. 279: 13241-13248.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

D. Loayza and T. de Lange (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature, 423: 1013-1018.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

R. Stansel, T. de Lange, J. D. Griffith (2001) T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J. 20: 5532-5540.

S. Hanaoka, A. Nagadoi, S. Yoshimura, S. Aimoto, B. Li, T. de Lange, Y. Nishimura (2001) NMR structure of the hRap1 Myb motif reveals a canonical three helix bundle lacking the positive surface charge typical of Myb DNA binding domains. J. Mol. Biol. 312: 167-175.

L. Fairall, L.Chapman, H. Moss, T. de Lange, D. Rhodes (2001). Structure of the TRFH dimerization Domain of the Human Telomeric Proteins TRF1 and TRF2. Mol. Cell 8: 351-361.

B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Cell 101: 471-483.

A. Bianchi, R. M. Stansel, L. Fairall, J. D. Griffith, D. Rhodes, T. de Lange (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J. 18: 5735-5744.

J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

J. Griffith, A. Bianchi, T. de Lange (1998) TRF1 promotes parallel pairing of telomeric DNA in vitro. J. Mol. Biol. 278: 79-88.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.

D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.

B. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-744.

Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 7: 1785-1794.

D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Human Mol. Genet. 6: 69-76.

B. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-744.

L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

J.P. Hanish, J. Yanowitz, T. de Lange (1994) Stringent sequence requirements for telomere formation in human cells. Proc. Natl. Acad. Sci. USA 91: 8861-8865.

T. de Lange (1992) Human telomeres are attached to nuclear matrix. EMBO J. 11: 717-724.

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Relevant PublicationsBack to main pageT. de Lange (2018) Shelterin-mediated telomere protection. Ann. Rev. Genetics: in press.T. De Lange (2018) What I got wrong about shelterin. J. Biol. Chem.