Telomeres and cancer: tumor suppression and genome instability
Relevant Publications
Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. 15: 1579-1586.
J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol 18: 175-186.
J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.
C.A. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Petrini, P.A. Sung, M. Jasin, J. Rosenbluh, Y. Zwang, B.A. Weir, C. Hatton, E. Ivanova, L. Macconaill, M. Hanna, W.C. Hahn, N.F. Lue, R.R. Reddel, Y. Jiao, K. Kinzler, B. Vogelstein, N. Papadopoulos, A.K. Meeker. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772
T. Davoli and T. de Lange (2012) Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation in mouse cells. Cancer Cell 21: 765-776.
T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.
T. Davoli & T. de Lange (2011) The Causes and Consequences of Polypolidy in Normal Development and Cancer. Annu. Rev. Cell Dev. Biol, 27: 585-610
T. de Lange (2005) Telomere-related genome instability in cancer. CSH Symp. Quant. Biol. 70: 197-204.
J.J.L. Jacobs and T. de Lange (2005) p16INK4as a second effector of the telomere damage response. Cell Cycle 4: 1364-1368.
J.J.L. Jacobs and T. de Lange (2004) Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr. Biol. 14: 1-20.
A. Smogorzewska and T. de Lange (2002). Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21: 4338-4348.
J Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.
J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell92: 401-413.
T. de Lange (1998) Telomeres and senescence: ending the debate. Science 279: 334-335.
T. de Lange (1995) Telomere dynamics and genome instability in human cancer. Telomeres. E.H. Blackburn and C.W. Greider, eds. CSH press, pp. 265-293.
D. Broccoli, J.W. Young, T. de Lange (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92: 9082-9086.
T. de Lange (1994) Activation of telomerase in a human tumor. Proc. Natl. Acad. Sci. USA 91: 2882-2885.
T. de Lange, L. Shiue, R.M. Myers, D.R. Cox, S.L. Naylor, A.M. Killery, H.E. Varmus (1990) Structure and variability of human chromosome ends. Mol. Cell. Biol. 10: 518-527.
