Past Member Publications

Postdoctoral Fellows and Associates

Nazario Bosco's Publications:

J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.

N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465

Pelliccia F*, Bosco N*, Rocchi A (2010) Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S. Cancer Lett, 299(1): 37-44. (*co-first authors)

Bosco N, Pelliccia F, Rocchi A (2010) Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region. Cancer Genet Cytogenet, 202(1): 47-52.

Pelliccia F, Bosco N, Curatolo A, Rocchi A (2008) Replication timing of two human common fragile sites: FRA1H and FRA2G. Cytogenet Genome Res, 121(3-4):196-200.

Pelliccia F, Curatolo A, Limongi MZ, Bosco N, Rocchi A (2007) Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. Cancer Genetics and Cytogenetics,178: 144-150
 

John Maciejowski's Publications  

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. 15: 1579-1586.

J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instabilityNat Rev Mol Cell Biol 18: 175-186.

J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.

 

Yi Gong's Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

Y. Gong, N. Handa, S.C. Kowalczykowski & T. de Lange (2017) PHF11 promotes DSB resection, ATR signaling, and HRGenes Dev 31: 46-58.

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.

Y Gong, JN Lee, PC Lee, Jl Goldstein, MS Brown, J Ye (2006) Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism 3:15-24.

Y Gong, JN Lee, MS Brown, Jl Goldstein, J Ye (2006) Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Nat Acad Sci 103: 6154-6159.

JN Lee, Y Gong, X Zhang, J Ye (2006) Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Nat Acad Sci 103: 4958-4963.

T Yang, PJ Espenshade, ME Wright, D Yabe, Y Gong, R Aebersold, Jl Goldstein, MS Brown (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110: 489-500.

G Zhou, H Li, Y Gong, Y Zhao, J Cheng, P Lee, Y Zhao (2005) Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. Proteomics 5: 3814-3821.

G Zhou, H Li, D DeCamp, S Chen, H Shu, Y Gong, M Flaig, JW Gillespie, N Hu, PR Taylor, LA Liotta, MR Emmert-Buck, EF Petricoin III, Y Zhao (2002) 2D differential in-gel electrophoresis for the identification of esophageal squamous cell cancer-specific protein markers. Mol Cell Proteomics 1: 117-124.

DW Yu, T Yang, T Sonoda, Y Gong, Q Cao, K Gaffney, PJ Jensen, IM Freedberg, RM Lavker, TT Sun (2001) Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. J Invest Dermatology 117: 1554-1558.

Y Gong, KD Liu, G Zhou, Q Xie, SL Chen, ZY Tang (1998) Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft. World J Gastroenterology 4: 7-9.

 

Francisca Lottersberger's Publications 

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair.  Cell 163: 880-893.  

M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA 110: 2146-2151. **equal contribution. *corresponding author.

 

Katja Kratz's Publications:

K. Kratz & T. de Lange (2018) Both Protection of Telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion but binding to CST limits ATR repression by POT1b. J Biol Chem: ePub ahead of print

F. Erdel, K. Kratz, S. Willcox, J.D. Griffith, E.C. Greene & T. de Lange (2017) Telomere Recognition and Assembly Mechanism of Mammalian Shelterin. Cell Rep 18: 41-53.

C. Dittrich, K. Kratz, A. Sendoel, Y. Gruenbaum, J. Jiricny, and M.O. Hengartner. (2012). LEM-3 - a novel endonuclease involved in the DNA damage response. PLoS One 7(2):e24555

K. Kratz, B. Schopf, S. Kaden, A. Sendoel, R. Eberhard, C. Lademann, E. Cannavo, AA Sartori, MO Hengartner, J. Jiricny. (2010). Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142, 77-88.

K. Yoshikiyo, K. Kratz, K. Hirota, I. Nishihara, M. Takata, H. Kurumizaka, S. Horimoto, S. Takeda, J. Jiricny. (2010). KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. PNAS 107, 21553-21557.

 

Tatsuya Kibe's Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

T. Kibe, M. Zimmermann & T. de Lange (2016) TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell 61: 236-246

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.

T Kibe, Y Ono, K Sato, M Ueno (2007) Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss. Mol Biol Cell 18: 2378-2387

K Tomita, T Kibe, HY Kang, YS Seo, M Uritani, T Ushimaru, M Ueno (2004) Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol Cell Biol 24: 9557-9567

 

Ylli Doksani's Publications  

Y. Doksani & T.  de Lange (2016) Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep. 17: 1646-1656.

Y. Doksani, and T de Lange (2014)  The role of double-strand break repair pathways at functional and dysfunctional telomeres.  Cold Spring Harb. Perspect. Biol. 2014 6: 1-15

Y. Doksani*, J.Y. Wu*, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356.  *equal contribution

 

David Frescas' Publications:

D. Frescas, and T. de Lange (2014). Binding of TPP1 to TIN2 is required for POT1a,b-mediated telomere protection. J Biol Chem 289: 24180-24187.

D. Frescas, and T. de Lange (2014). TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1. Mol Cell Biol 34: 1349-1362.

D. Frescas and T. de Lange (2014)A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in miceGenes and Development 28: 153-166.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

 

Agnel Sfeir's Publications

A.S. Tong, J.L. Stern, A. Sfeir, M. Kartawinata, T. de Lange, X.-D. Zhu, T.M. Bryan (2015) ATM and ATR signaling regulate the recruitment of telomerase to telomeres. Cell Reports 13: 1633- 1646

M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597.

H. Scherthan, A. Sfeir, and T. de Lange (2011) Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma 120: 151-157.

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

 

Eros Lazzerini Denchi's Publications: 

T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448:1068-71.

E. Lazzerini Denchi, G.B. Celli and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.

G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol. 8: 855-862.

 

Sean Rooney's Publications:

P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.

 

Akimitsu Konishi's Publications:

A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes and Development 22(9):1221-30.

 

Sara Buonomo's Publications:

M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

S. Buonomo, Y. Wu, D. Ferguson, T. de Lange (2009) Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187:385-398.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

  

Diego Loayza's Publications:

D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5’-TAGGGTTAG-3’ minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem  279: 13241-13248.

D. Loayza and T. de Lange (2004) Telomerase regulation at the telomere: a binary switch. Cell 117: 279-280.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem, 279: 47264-47271.

D. Loayza and T. de Lange (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423: 1013-1018.

  

Giulia Celli's Publications:

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol 8: 855-862.

E. Lazzerini Denchi, G.B. Celli, and Titia de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.

G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol 7: 712-718.

  

Jeff Ye's Publications:

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. NatureStructural and Molecular Biology 8:754-61.

J. Z.-S. Ye and T. de Lange (2004) TIN2 is a tankyrase 1 PARP-modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

J.Z.-S. Ye, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem, 279: 47264-47271.

  

Jacqueline Jacob's Publications:

J.J.L. Jacobs and T. de Lange (2005) p16INK4as a second effector of the telomere damage response. Cell Cycle 4: 1364-1368.

J.J.L. Jacobs and T. de Lange (2004) Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 14: 1-20.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448:1068-71.  

 

Xu-Dong Zhu's Publications:
X.-D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J. H. J. Hoeijmakers, and T. de Lange (2003) ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA containing double minute chromosomes.  MolCell, 6: 1489-1498.

X.-D. Zhu, B. Küster, M. Mann, J.H.J. Petrini, and T. de Lange (2000) Cell cycle regulated association of the Rad50/Mre11/Nbs1 complex with TRF2 and human telomeres.  NatureGenetics 25: 347-352.

L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.

  

Jan Karlseder's Publications:
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

J. Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295:  2446-2449.

A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr. Biol 12: 1634-1644.

J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

  

Bibo Li's Publications:
B. Li and T. de Lange (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell 14: 5060-5068.

S. Hanaoka, A. Nagadoi, S. Yoshimura, S. Aimoto, B. Li, T. de Lange, Y. Nishimura (2001) NMR structure of the hRap1 Myb motif reveals a canonical three helix bundle lacking the positive surface charge typical of Myb DNA binding domains. J. Mol. Biol 312:  167-175.

B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Cell 101: 471-483.

H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000). Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol Bio Cell 11: 4189-4203.

  

Susan Smith's Publications:
S. Smith and T. de Lange (2000) Tankyrase promotes telomere elongation. Current Biol10: 1299-1302.

H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000) Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol Biol Cell 11: 4189-4203.

L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.

S. Smith, T. de Lange (1999) Cell cycle dependent localization of tankyrase, a telomeric PARP, to centrosomes and nuclear pore complexes. J. Cell Sci. 112: 3649-3656.

S. Smith, I. Giriat, A. Schmitt, T. de Lange (1998) Tankyrase, a poly(ADP-ribose)polymerase at human telomeres.  Science 282: 1484-1488.

S. Smith and T. de Lange (1997) TRF1, a mammalian telomeric protein. TIG 13: 21-26.

A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J 7: 1785-1794.

  

Dominique Broccoli's Publications:
J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. HumanMol. Genet 6: 69-76.

D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.

D. Broccoli, L.A. Godley, L.A. Donehower, H.E. Varmus, T. de Lange (1996)  Telomerase activation in mouse mammary tumors: lack of telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol 16: 3765-3772.

D. Broccoli, J.W. Young, T. de Lange (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc Nat Acad Sci USA 92: 9082-9086.

L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

  

Bas van Steensel's Publications:
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

M.E.E. Ludérus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J Cell Biol 135: 867-883.

D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Human Mol Genet 6: 69-76.

B. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-744.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.

A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20: 1659-1668.

  

Eva Luderus' Publications:
M.E.E. Ludérus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J Cell Biol 135: 867-883.

 

John Hanish's Publications:
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

J.P. Hanish, J. Yanowitz, T. de Lange (1994) Stringent sequence requirements for telomere formation in human cells. Proc Natl Acad Sci USA 91: 8861-8865.

  

Maria Cardenas' Publications:
M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes & Dev 7: 883-894.

 

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Graduate Students 

Roos Anna Karssemeijer's Publications:
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair.  Cell 163: 880-893.  

S.K. Dougan, J. Ashour, R.A. Karssemeijer, M.W. Popp, A.M. Avalos, M. Barisa, A.F. Altenburg, J.R. Ingram, J.J. Cragnolini, C. Guo, F.W. Alt, R. Jaenisch, and H.L. Ploegh (2013). Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature 503: 406-409.

H.A. Schreiber, J. Loschko, R.A. Karssemeijer, A. Escolano, M.M. Meredith, D. Mucida, P. Guermonprez, and M.C. Nussenzweig (2013). Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J. Exp. Med. 210: 2025-2039.

M.W. Popp, R.A. Karssemeijer, and H.L. Ploegh (2012). Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. PLoS Pathog. 8: e1002604.

J.S. Yount, R.A. Karssemeijer, and H.C. Hang (2012). S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J. Biol. Chem. 287: 19631-19641.

C.E. van der Poel, R.A. Karssemeijer, P. Boross, J.A. van der Linden, M. Blokland, J.G. van de Winkel, and J.H. Leusen (2010). Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcgammaRI, in the presence of monomeric IgG. Blood 116: 5327-5333.


Shaheen Kabir's Publications:

S. Kabir, D. Hockemeyer, T. de Lange (2014). TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Cell Rep 9:1273-1280

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalScience 327: 1657-1661.

BQ Vuong, M Lee, S Kabir, C Irimia, S Macchiarulo, GS McKnight, J Chaudhuri (2009) Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10: 420-426

 

Michal Zimmerman's Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

M. Zimmermann, T. Kibe, S. Kabir,  T. de Lange (2014). TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev 28: 2477-2491.

M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

M. Zimmermann, and T. de Lange (2013). 53BP1: pro choice in DNA repair. Trends Cell Biol 24: 108-117.

F. Hobor, R. Pergoli, K. Kubicek, D. Hrossova, V. Bacikova, M. Zimmermann, J. Pasulka, C. Hofr, S. Vanacova, and R. Stefl (2011). Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein. J Biol Chem 286: 3645-3657.

R. Stefl, F.C. Oberstrass, J.L. Hood, M. Jourdan, M. Zimmermann, L. Skrisovska, C. Maris, L. Peng, C. Hofr, R.B. Emeson, and F.H. Allain (2010). The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell 143: 225-237.

M. Varecha, M. Zimmermann, J. Amrichova, V. Ulman, P. Matula, and M. Kozubek (2009). Prediction of localization and interactions of apoptotic proteins. J Biomed Sci 16: 59.

C. Hofr, P. Sultesova, M. Zimmermann, I. Mozgova, P. Prochazkova Schrumpfova, M. Wimmerova, and J. Fajkus (2009). Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics. Biochem J 419: 221-8, 2 p following 228.

M. Varecha, J. Amrichova, M. Zimmermann, V. Ulman, E. Lukasova, and M. Kozubek (2007). Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. Apoptosis 12: 1155-1171.

 

Teresa Davoli's Publications:
T. Davoli and T. de Lange (2012) Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation in mouse cells. Cancer Cell 21: 765-776

T. Davoli & T. de Lange (2011) The Causes and Consequences of Polypolidy in Normal Development and Cancer. Annu. Rev. Cell Dev. Biol, 27: 585-610

T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.

 

Peng Wu's Publications:
P. Wu, H. Taka and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.

P Wu and T de Lange (2008) No Overt Nucleosome Eviction at Deprotected Telomeres. Mol Cell Biol 28: 5724-5735

  

Megan van Overbeek's Publications:

P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 606-617.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, and Lei M (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.

van Overbeek M and de Lange T (2006) Apollo, an Artemis related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol 16: 1295-1302.

Ye JZ-S, Donigian J, van Overbeek M, Loayza D, Chait B, Krutchinsky A, and de Lange T (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279: 47264-47271.

  

Nadya Dimitrova's Publications:
F. Lottersberger, R.A. Karssemeijer, N. Dimitrova, T. de Lange (2015) 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair.  Cell 163: 880-893.  

N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell. Biol. 290:5552-5563.

N. Dimitrova, Telomere binding proteins in human cells. Cancer Drug Discovery & Development: Telomeres and Telomerase in Cancer. Humana Press Inc. (2009).

N. Dimitrova, YC. Chen, DL. Spector, T. de Lange (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456(7221):524-8.

N. Dimitrova and T. de Lange (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes and Development 20: 3238-3243.

  

Jill Donigian's Publications:
Y. Chen, Y. Yang, M. van Overbeek, and J. Donigian (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.

D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem 279: 13241-13248.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279: 47264-47271.

J. R. Donigian and T. de Lange (2007) The role of tankyrase1 in telomere length control by TRF1. J Biol Chem 282: 22662-7.

  

Dirk Hockemeyer's Publications:
S. Kabir, D. Hockemeyer, T. de Lange (2014). TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation. Cell Rep 9:1273-1280

A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.

D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes and Development online DOI:10.1101/gad.1679208

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. NatureStructural and Molecular Biology, 8:754-61.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange
(2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

  

Kristina Hoke's Publications:
D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem 279: 13241-13248.

J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.

 

  

Richard Wang's Publications
D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

X. Dong, M.A. Michelis, J. Wang, R. Bose, T. de Lange, W.H. Reeves (1998) Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. Arthritis Rheum. 41:1505-1510.

  

Joshua Silverman's Publications:
J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

  

Agata Smogorzewska's Publications:
A. Smogorzewska and T. de Lange (2004) Regulation of telomerase by telomeric proteins. Ann Rev Biochem 73: 177-208.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13: 1549-1556.

J. Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.

A. Smogorzewska and T. de Lange (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J 21: 4338-4348.

A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr Biol 12: 1634-1644.

A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2.  Mol. Cell Biol. 20: 1659-1668.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.

D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.

  

Alessandro Bianchi's Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20: 1659-1668.

J. D. Griffith, L. Comeau, S. Rosenfield, R. Stansel, A. Bianchi, H. Moss, T. de Lange. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514.

A. Bianchi and T. de Lange (1999) Ku binds telomeric DNA in vitro. J Biol Chem 274: 21223-21227.

A. Bianchi, R. M. Stansel, L. Fairall, J. D. Griffith, D. Rhodes, T. de Lange (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J 18: 5735-5744.

J. Griffith, A. Bianchi, T. de Lange (1998) TRF1 promotes parallel pairing of telomeric DNA in vitro. J Mol Biol 278: 79-88.

A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J 7: 1785-1794.

M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes & Dev 7: 883-894.

  

Henrik Tommerup's Publications:
H. Tommerup, A. Dousmanis, T. de Lange (1994) Unusual chromatin in human telomeres. Mol Cell Biol 14: 5777-5785.


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Postdoctoral Fellows and AssociatesNazario Bosco's Publications:J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis.