de Lange lab genetically altered mouse embryonic fibroblast cells (MEFs)

The following genetically altered mouse embryonic fibroblast cells (MEFs) are available from ATCC:

 

TRF1 flox

Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.Cell.138:90-103.

ATCC URL: https://www.atcc.org/Products/All/CRL-3316

ATCC number: CRL-3316

 

TRF2 flox

Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2.Nature Cell Biol. 7: 712-718.

ATCC URL: https://www.atcc.org/Products/All/CRL-3317

ATCC number: CRL-3317

 

Rap1 flox

Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

ATCC URL: https://www.atcc.org/Products/All/CRL-3319

ATCC number: CRL-3319

 

TIN2 flox

Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

ATCC URL: https://www.atcc.org/Products/All/CRL-3318

ATCC number: CRL-3318

 

TPP1 flox

Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1bMol. Cell. Biol. 30: 1059-1066.

ATCC URL: https://www.atcc.org/Products/All/CRL-3320

ATCC number: CRL-3320

 

POT1a flox

Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3321

ATCC number: CRL-3321

 

POT1b flox

Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3322

ATCC number: CRL-3322

 

POT1a/b flox

Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

ATCC URL: https://www.atcc.org/Products/All/CRL-3323

ATCC number: CRL-3323

 

Tel2 flox

Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

ATCC URL: https://www.atcc.org/Products/All/CRL-3324

ATCC number:  CRL-3324

The following genetically altered mouse embryonic fibroblast cells (MEFs) are available from ATCC: TRF1 floxSfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkr