Current Member Publications

Postdoctoral Fellows and Associates

 

 

Sally Dewhurst Publications:

A. Crockford, L.P. Zalmas, E. Grönroos, S.M. Dewhurst, N. Mcgranahan, M.E. Cuomo, V. Encheva, A.P. Snijders, J. Begum, S. Purewal, J. Cerveira, H. Patel, M.J. Renshaw & C. Swanton (2017.) Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. Ann Oncol 28: 149-156.

L. Sansregret, J.O. Patterson, S. Dewhurst, C. López-García, A. Koch, N. Mcgranahan, W.C. Chao, D.J. Barry, A. Rowan, R. Instrell, S. Horswell, M. Way, M. Howell, M.R. Singleton, R.H. Medema, P. Nurse, M. Petronczki & C. Swanton (2017.) APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discov 7: 218-233.

S. Dewhurst & C. Swanton (2015.) Tetraploidy and CIN: a dangerous combination. Cell Cycle 14: 3217.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

M. Gerlinger, N. Mcgranahan, S.M. Dewhurst, R.A. Burrell, I. Tomlinson & C. Swanton (2014.) Cancer: evolution within a lifetime. Annu Rev Genet 48: 215-236.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

R.A. Burrell, S.E. Mcclelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, S.K. Chew, A.J. Rowan, A. Schenk, M. Sheffer, M. Howell, M. Kschischo, A. Behrens, T. Helleday, J. Bartek, I.P. Tomlinson & C. Swanton (2013.) Replication stress links structural and numerical cancer chromosomal instability. Nature 494: 492-496.

   

Courtney Lovejoy Publications:
C.A. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Petrini, P.A. Sung, M. Jasin, J. Rosenbluh, Y. Zwang, B.A. Weir, C. Hatton, E. Ivanova, L. Macconaill, M. Hanna, W.C. Hahn, N.F. Lue, R.R. Reddel, Y. Jiao, K. Kinzler, B. Vogelstein, N. Papadopoulos, A.K. Meeker. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772 * corresponding author.

T Wiltshire, CA Lovejoy, T Wang, F Xia, MJ O'Connor, and D Cortez, (2010) Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem 285: 14565-14571

CA Lovejoy, X Xu, CE Bansbach, GG Glick, R Zhao, F Ye, BM Sirbu, LC Titus, Y Shyr, D Cortez (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc Nat Acad Sci 106: 19304-19309.

CE Bansbach, R Betous, CA Lovejoy, GG Glick, D Cortez (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev 23: 2405-2414.

CA Lovejoy, D Cortez (2009) Common mechanisms of PIKK regulation. DNA Repair (Amst) 8: 1004-1008.

CA Lovejoy, K Lock, A Yenamandra, D Cortez (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 21: 7977-90.

AJ Danielsen, TA Christensen, CA Lovejoy, MA Adelsman, DC Connolly, NJ Maihle (2004) Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation. Exp Cell Res 2: 285-293.

JL Boerner, AJ Danielsen, CA Lovejoy, Z Wang, SC Juneja, JM Faupel-Badger, JR Darce, NJ Maihle (2003) Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22: 6679-6689.

 

Logan Myler's Publications

L.R. Myler & I.J. Finkelstein (2017.) Eukaryotic resectosomes: A single-molecule perspective. Prog Biophys Mol Biol 127: 119-129.

L.R. Myler, I.F. Gallardo, M.M. Soniat, R.A. Deshpande, X.B. Gonzalez, Y. Kim, T.T. Paull & I.J. Finkelstein (2017.) Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair. Mol Cell 67: 891-898.e4.

M.M. Soniat, L.R. Myler, J.M. Schaub, Y. Kim, I.F. Gallardo & I.J. Finkelstein (2017.) Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination. Methods Enzymol 592: 259-281.

L.R. Myler, I.F. Gallardo, Y. Zhou, F. Gong, S.H. Yang, M.S. Wold, K.M. Miller, T.T. Paull & I.J. Finkelstein (2016.) Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins. Proc Natl Acad Sci U S A 113: E1170-9.

J.H. Lee, Z. Guo, L.R. Myler, S. Zheng & T.T. Paull (2014.) Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One 9: e97969.

 

  

Nanda Sasi Publications:

N.K. Sasi, A. Bhutkar, N.J. Lanning, J.P. Mackeigan & M. Weinreich (2017.) DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia 19: 439-450.

N.K. Sasi, K. Tiwari, F.F. Soon, D. Bonte, T. Wang, K. Melcher, H.E. Xu & M. Weinreich (2014.) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One 9: e113300.

L. Woodbine, J.A. Neal, N.K. Sasi, M. Shimada, K. Deem, H. Coleman, W.B. Dobyns, T. Ogi, K. Meek, E.G. Davies & P.A. Jeggo (2013.) PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest 123: 2969-2980.

 

Isabelle Schmutz Publications:

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397.

I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev 24(4): 345-357. PMCID: PMC2816734

F. Stadler, I. Schmutz, B. Schwaller, and U. Albrecht (2010) Lack of calbindin-D28K alters response of the murine circadian clock to light. Chronobiol. Int, 27(1): 68-82

M. Darna, I. Schmutz, K. Richter, S.V. Yelamanchili, G. Pendyala, M. Holtje, U. Albrecht, G. Ahnert-Hilger (2009) Time of Day-dependent Sorting of the Vesicular Glutamate Transporter to the Plasma Membrane. J Biol Chem 284: 4300-4307

G. Hampp, J.A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perreau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J.H. Meijer, U. Albrecht (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol 18: 678-683

MA Farre-Castany, B Schwaller, P Gregory, J Barski, C Mariethoz, JL Eriksson, IV Tetko. D Wolfer, MR Celio, I Schmutz, U Albrecht, AE Villa (2007) Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbulin, calbindin D-28k or both. Behav Brain Res 178: 250-261

C Jud, I Schmutz, G Hampp, H Oster, U Albrecht (2005) A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol Proced Online 7: 101-116

 

Hiro Takai Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

H. Takai, E. Jenkinson, S. Kabir, R. Babul-Hirji, N. Najm-Tehrani, D.A. Chitayat, Y.J. Crow & T. de Lange (2016) A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plusGenes Dev 30: 812-826.

E.A. Ahmed, A. Sfeir, H. Takai, and H. Scherthan (2013). Ku70 and non-homologous end joining protect testicular cells from DNA damage. J Cell Sci 126: 3095-3104.

P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

Z. Horejsi, H. Takai, S. Collins, H. Flynn, S. Maslen, J.M. Skehel, T. de Lange, and S. Boulton (2010) CK2 phospho-dependent binding of R2TP complex to Tel2 is essential for mTOR and SMG1 stability. Mol. Cell, 39:839-850.

H. Takai, Y. Xiey*, T. de Lange** and N.P. Pavletich** (2010) Tel2 is a helical repeat protein that mediates Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24: 2019-2030.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

L Cao, S Kim, C Xiao, R Wang, X Coumoul, X Wang, WM Li, X XuL, JA De Soto, H Takai, S Mai, SJ Elledge, N Motoyama, CX Deng. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 25: 2167-77.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

MT Jack, RA Woo, N Motoyama, H Takai, Lee PW. (2004) DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 279: 15269-15273.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

H Takai, K Naka, M Watanabe, Y Okada, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.  EMBO J  21: 5195-5205

K Kobayashi, M Watanabe, Y Okada, H Takai, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Hydrocephalus and male infertility in DNA polymerase alpha-deficient mice. Mol Cell Biol 22: 2769-2776

T Sasaki, S Kamimura, H Takai, A Watanabe, K Onitake (2002) The activity for the induction of the sperm acrosome reaction localizes in the outer layers and exists in the high-molecular-weight components of the egg-jelly of the newt, Cynops pyrrhogaster. Zygote 10: 1-9

H Takai, K Tominaga, N Motoyama, YA Minamishima, H Nagahama, T Tsukiyama, K Ikeda, K Nakayama, M Nakanishi, K Nakayma K. (2000) Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice. Genes Dev 14: 1439-1447

M Kanematsu, T Sato, H Takai, K Watanabe, K Ikeda, Y Yamada. (2000) PGE2 induces expression of RANKL on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency.  J Bone Miner Res 15: 1321-1329

K Onitake, H Takai, M Ukita, JI Mizuno, T Sasaki, A Watanabe. (2000) Significance of egg-jelly substances in the internal fertilization of the newt, Cynops pyrrhogaster. Comp Biochem Physiol B Biochem Mol Biol 126: 121-128

H Mohri, K Inaba, M Kubo-Irie, H Takai, Y Yano-Toyoshima. (1999) Characterization of outer arm dynein in sea anemone, Anthopleira midori. Cell Motil Cytoskeleton 44: 202-208

H Takai, M Kanematsu, K Yano, E Tsuda, K Higashio, K Ikeda, K Watanabe, Y Yamada. (1998) TGF-β stimulates the production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by bone marrow stromal cells.  J Biol Chem 273: 27091-27096

M Kanematsu, H Takai, Y Yamada. (1998) Actions of nitric oxide in the regulation of osteoclasts and osteoblasts. Curr Opinion Orthopedics 9: 11-16

Y Yamada, A Miyauti, J Goto, Y Takagi, H Okuizumi, M Kanematsu, M Hase, H Takai, A Harada, K Ikeda. (1998) Association of a polymorphism of the Transforming Growth Factor β-1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13: 1569-1576

T Kameda, H Mano, Y Yamada, H Takai, N Amizuka, M Kobori, N Izumi, H Kawasima, H Ozawa, K Ikeda, A Kameda, Y Hakeda, M Kumegawa (1998) Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells.  Biochem Biophys Res Commun 245: 419-422.

K Ogawa, H Takai, A Ogiwara, E Yokota, T ShimizuT, K Inaba, H Mohri. (1996) Is outer arm dynein intermediate chain 1 multifunctional? Mol Biol Cell 7: 1895-1907

H Shimizu, T Majima, H Takai, K Inaba, T Tomie (1995) Morphological changes of wrasse sperm axoneme after their motility initiation observed with use of atomic force microscopy. SPIE 2384: 45-51.

H Takai and M Morisawa (1995) Change in intracellular K+ concentration caused by external osmolality change regulates sperm motility of marine and freshwater teleosts.  J Cell Sci 108: 1175-1181

 

John Zinder's Publications

E.M. Weick, M.R. Puno, K. Januszyk, J.C. Zinder, M.A. Dimattia & C.D. Lima (2018) Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Cell 173: 1663-1677.e21.

E.V. Wasmuth, J.C. Zinder, D. Zattas, M. Das & C.D. Lima (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife 6

J.C. Zinder & C.D. Lima (2017) Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors. Genes Dev 31: 88-100.

J.C. Zinder, E.V. Wasmuth & C.D. Lima (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. Mol Cell 64: 734-745.

M.R. Wasserman, A. Pulk, Z. Zhou, R.B. Altman, J.C. Zinder, K.D. Green, S. Garneau-Tsodikova, J.H. Cate & S.C. Blanchard (2015) Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nat Commun 6: 7896.

E.M. Seco, J.C. Zinder, C.M. Manhart, A. Lo Piano, C.S. Mchenry & S. Ayora (2013) Bacteriophage SPP1 DNA replication strategies promote viral and disable host replication in vitro. Nucleic Acids Res 41: 1711-1721.

 

 

 

  

Graduate Students

Alexander Stuart Publications: 

Coming soon!

 

Charles Kinzig Publications:

J.A. Brown, C.G. Kinzig, S.J. Degregorio & J.A. Steitz (2016) Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix. RNA 22: 743-749.

J.A. Brown, C.G. Kinzig, S.J. Degregorio & J.A. Steitz (2016) Methyltransferase-like protein 16 binds the 3’-terminal triple helix of MALAT1 long noncoding RNA. Proc Natl Acad Sci U S A 113: 14013-14018.

 

Zachary Mirman Publications:

Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

A.C. Paré, A. Vichas, C.T. Fincher, Z. Mirman, D.L. Farrell, A. Mainieri & J.A. Zallen (2014) A positional Toll receptor code directs convergent extension in Drosophila. Nature 515: 523-527.

 

Leonid Timashev Publications:

L.A. Timashev, H. Babcock, X. Zhuang & T. de Lange (2017.) The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev 31: 578-589.

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

 

 

Zhe Yang's Publications:

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or RbMol. Cancer Res. 15: 1579-1586.

K.K. Lim, T.Y. Ong, Y.R. Tan, E.G. Yang, B. Ren, K.S. Seah, Z. Yang, T.S. Tan, B.W. Dymock & E.S. Chen (2015.) Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Sci Rep 5: 14064

  

Research Assistants

Kaori Takai Publications:
Z. Mirman, F. Lottersberger, H. Takai, T. Kibe, Y. Gong, K. Takai, A. Bianchi, M. Zimmermann, D. Durocher & Titia de Lange (2018) 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.  Nature: 560: 112-116.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. Chem. 285: 1457-1467.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.

E Itakura, K Takai, K Umeda, M Kimura, M Ohsumi, K Tamai, and A Matsuura, (2004) Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett 577: 289-293

C Kitazawa, K Takai, Y Nakajima, H Fujisawa, S Amemiya, (2004) LiCl inhibits the establishment of left-right asymmetry in larvae of the direct-developing echinoid Peronella japonica. J Exp Zool A Comp Exp Biol FEBS Lett Cell Struct Funct Hepatology 301: 707-17

K Takai, S Hattori, and S Irie, (2001) Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct 26: 289-302

C Tateno, K Takai-Kajihara, C Yamasaki, H Sato, and K Yoshizato, (2000) Heterogeneity of growth potential of adult rat hepatocytes in vitro. Hepatology 31: 65-74

 

Postdoctoral Fellows and Associates  Sally Dewhurst Publications:A. Crockford, L.P. Zalmas, E. Grönroos, S.M. Dewhurst, N. Mcgranahan, M.E. Cuomo, V. Encheva, A.P. Snijders