Current Member Publications

Postdoctoral Fellows and Associates

 

Nazario Bosco Publications:

N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465

Pelliccia F*, Bosco N*, Rocchi A (2010) Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S. Cancer Lett, 299(1): 37-44. (*co-first authors)

Bosco N, Pelliccia F, Rocchi A (2010) Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region. Cancer Genet Cytogenet, 202(1): 47-52.

Pelliccia F, Bosco N, Curatolo A, Rocchi A (2008) Replication timing of two human common fragile sites: FRA1H and FRA2G. Cytogenet Genome Res, 121(3-4):196-200.

Pelliccia F, Curatolo A, Limongi MZ, Bosco N, Rocchi A (2007) Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. Cancer Genetics and Cytogenetics,178: 144-150.Sally Dewhurst Publications:

R.A. Burrell, S.E. Mcclelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, S.K. Chew, A.J. Rowan, A. Schenk, M. Sheffer, M. Howell, M. Kschischo, A. Behrens, T. Helleday, J. Bartek, I.P. Tomlinson & C. Swanton (2013.) Replication stress links structural and numerical cancer chromosomal instability. Nature 494: 492-496.

Dewhurst & C. Swanton (2015.) Tetraploidy and CIN: a dangerous combination. Cell Cycle 14: 3217.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

Gerlinger, N. Mcgranahan, S.M. Dewhurst, R.A. Burrell, I. Tomlinson & C. Swanton (2014.) Cancer: evolution within a lifetime. Annu Rev Genet 48: 215-236.

 

 

Sally Dewhurst Publications:

A. Crockford, L.P. Zalmas, E. Grönroos, S.M. Dewhurst, N. Mcgranahan, M.E. Cuomo, V. Encheva, A.P. Snijders, J. Begum, S. Purewal, J. Cerveira, H. Patel, M.J. Renshaw & C. Swanton (2017.) Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. Ann Oncol 28: 149-156.

L. Sansregret, J.O. Patterson, S. Dewhurst, C. López-García, A. Koch, N. Mcgranahan, W.C. Chao, D.J. Barry, A. Rowan, R. Instrell, S. Horswell, M. Way, M. Howell, M.R. Singleton, R.H. Medema, P. Nurse, M. Petronczki & C. Swanton (2017.) APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discov 7: 218-233.

S. Dewhurst & C. Swanton (2015.) Tetraploidy and CIN: a dangerous combination. Cell Cycle 14: 3217.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

M. Gerlinger, N. Mcgranahan, S.M. Dewhurst, R.A. Burrell, I. Tomlinson & C. Swanton (2014.) Cancer: evolution within a lifetime. Annu Rev Genet 48: 215-236.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

R.A. Burrell, S.E. Mcclelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, S.K. Chew, A.J. Rowan, A. Schenk, M. Sheffer, M. Howell, M. Kschischo, A. Behrens, T. Helleday, J. Bartek, I.P. Tomlinson & C. Swanton (2013.) Replication stress links structural and numerical cancer chromosomal instability. Nature 494: 492-496.

 

 

Yi Gong Publications:

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.

Y Gong, JN Lee, PC Lee, Jl Goldstein, MS Brown, J Ye (2006) Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism 3:15-24.

Y Gong, JN Lee, MS Brown, Jl Goldstein, J Ye (2006) Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Nat Acad Sci 103: 6154-6159.

JN Lee, Y Gong, X Zhang, J Ye (2006) Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Nat Acad Sci 103: 4958-4963.

T Yang, PJ Espenshade, ME Wright, D Yabe, Y Gong, R Aebersold, Jl Goldstein, MS Brown (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110: 489-500.

G Zhou, H Li, Y Gong, Y Zhao, J Cheng, P Lee, Y Zhao (2005) Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. Proteomics 5: 3814-3821.

G Zhou, H Li, D DeCamp, S Chen, H Shu, Y Gong, M Flaig, JW Gillespie, N Hu, PR Taylor, LA Liotta, MR Emmert-Buck, EF Petricoin III, Y Zhao (2002) 2D differential in-gel electrophoresis for the identification of esophageal squamous cell cancer-specific protein markers. Mol Cell Proteomics 1: 117-124.

DW Yu, T Yang, T Sonoda, Y Gong, Q Cao, K Gaffney, PJ Jensen, IM Freedberg, RM Lavker, TT Sun (2001) Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. J Invest Dermatology 117: 1554-1558.

Y Gong, KD Liu, G Zhou, Q Xie, SL Chen, ZY Tang (1998) Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft. World J Gastroenterology 4: 7-9.

 

 

Francisca Alessandra Lottersberger Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA, 110: 2146-2151. **equal contribution. *corresponding author.

F Lottersberger , A Panza, G Lucchini, MP Longhese (2007) Functional and physical interactions between yeast 14-3-3, acetyltransferase and deacetylase proteins in response to DNA replication stress. Mol Cell Biol 27: 3266-3281.

F Lottersberger , A Panza, S Piatti, G Lucchini, MP Longhese (2006) The Saccharomyces cerevisiae 14-3-3 Proteins Are Required for the G1/S Transition, Actin Cytoskeleton Organization and Cell Wall Integrity. Genetics 173 : 661-675.

M Clerici, V Baldo, D Mantiero, F Lottersberger , G Lucchini, MP Longhese (2004) A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol 24: 10126-10144.

F Lottersberger , F Rubert, V Baldo, G Lucchini, and MP Longhese (2003) Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress. Genetics 165 :1717-1732.

 

 

Courtney Lovejoy Publications:
C.A. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Petrini, P.A. Sung, M. Jasin, J. Rosenbluh, Y. Zwang, B.A. Weir, C. Hatton, E. Ivanova, L. Macconaill, M. Hanna, W.C. Hahn, N.F. Lue, R.R. Reddel, Y. Jiao, K. Kinzler, B. Vogelstein, N. Papadopoulos, A.K. Meeker. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772 * corresponding author.

T Wiltshire, CA Lovejoy, T Wang, F Xia, MJ O'Connor, and D Cortez, (2010) Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem 285: 14565-14571

CA Lovejoy, X Xu, CE Bansbach, GG Glick, R Zhao, F Ye, BM Sirbu, LC Titus, Y Shyr, D Cortez (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc Nat Acad Sci 106: 19304-19309.

CE Bansbach, R Betous, CA Lovejoy, GG Glick, D Cortez (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev 23: 2405-2414.

CA Lovejoy, D Cortez (2009) Common mechanisms of PIKK regulation. DNA Repair (Amst) 8: 1004-1008.

CA Lovejoy, K Lock, A Yenamandra, D Cortez (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 21: 7977-90.

AJ Danielsen, TA Christensen, CA Lovejoy, MA Adelsman, DC Connolly, NJ Maihle (2004) Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation. Exp Cell Res 2: 285-293.

JL Boerner, AJ Danielsen, CA Lovejoy, Z Wang, SC Juneja, JM Faupel-Badger, JR Darce, NJ Maihle (2003) Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22: 6679-6689.

 

 

John Maciejowski Publications:

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. in press

J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol 18: 175-186.

J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.

Rodriguez-Bravo, J. Maciejowski, J. Corona, H.K. Buch, P. Collin, M.T. Kanemaki, J.V. Shah, and P.V. Jallepalli (2014). Nuclear pores protect genome integrity by assembling a premitotic and mad1-dependent anaphase inhibitor. Cell 156: 1017-1031.

Randall-Paschal C, Maciejowski J, Jallepalli PV. (2012) A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma 121: 565-572

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV (2010)  Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 190: 89-100

McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJ (2009) A “latent niche” mechanism for tumor initiation. Proc Natl Acad Sci USA. 106: 11617-22

Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7: e10000111

Maciejowski J, Ugel N, Mishra B, Isopi M, Hubbard EJ (2006) Quantitative analysis of germline mitosis in adult C. elegans. Dev Biol. 292: 142-51

Maciejowski J, Ahn JH, Cipriani PG, Killian DJ, Chaudhary AL, Lee JI, Voutev R, Johnsen RC, Baillie DL, Gunsalus KC, Fitch DH, Hubbard EJ (2005) Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics 169: 1997-2011
 
 

Nanda Sasi Publications:

N.K. Sasi, A. Bhutkar, N.J. Lanning, J.P. Mackeigan & M. Weinreich (2017.) DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia 19: 439-450.

N.K. Sasi, K. Tiwari, F.F. Soon, D. Bonte, T. Wang, K. Melcher, H.E. Xu & M. Weinreich (2014.) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One 9: e113300.

L. Woodbine, J.A. Neal, N.K. Sasi, M. Shimada, K. Deem, H. Coleman, W.B. Dobyns, T. Ogi, K. Meek, E.G. Davies & P.A. Jeggo (2013.) PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest 123: 2969-2980.

 

Isabelle Schmutz Publications:

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397.

I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev 24(4): 345-357. PMCID: PMC2816734

F. Stadler, I. Schmutz, B. Schwaller, and U. Albrecht (2010) Lack of calbindin-D28K alters response of the murine circadian clock to light. Chronobiol. Int, 27(1): 68-82

M. Darna, I. Schmutz, K. Richter, S.V. Yelamanchili, G. Pendyala, M. Holtje, U. Albrecht, G. Ahnert-Hilger (2009) Time of Day-dependent Sorting of the Vesicular Glutamate Transporter to the Plasma Membrane. J Biol Chem 284: 4300-4307

G. Hampp, J.A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perreau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J.H. Meijer, U. Albrecht (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol 18: 678-683

MA Farre-Castany, B Schwaller, P Gregory, J Barski, C Mariethoz, JL Eriksson, IV Tetko. D Wolfer, MR Celio, I Schmutz, U Albrecht, AE Villa (2007) Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbulin, calbindin D-28k or both. Behav Brain Res 178: 250-261

C Jud, I Schmutz, G Hampp, H Oster, U Albrecht (2005) A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol Proced Online 7: 101-116

 

Hiro Takai Publications:

E.A. Ahmed, A. Sfeir, H. Takai, and H. Scherthan (2013). Ku70 and non-homologous end joining protect testicular cells from DNA damage. J Cell Sci 126: 3095-3104.

P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

Z. Horejsi, H. Takai, S. Collins, H. Flynn, S. Maslen, J.M. Skehel, T. de Lange, and S. Boulton (2010) CK2 phospho-dependent binding of R2TP complex to Tel2 is essential for mTOR and SMG1 stability. Mol. Cell, 39:839-850.

H. Takai, Y. Xiey*, T. de Lange** and N.P. Pavletich** (2010) Tel2 is a helical repeat protein that mediates Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24: 2019-2030.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

L Cao, S Kim, C Xiao, R Wang, X Coumoul, X Wang, WM Li, X XuL, JA De Soto, H Takai, S Mai, SJ Elledge, N Motoyama, CX Deng. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 25: 2167-77.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

MT Jack, RA Woo, N Motoyama, H Takai, Lee PW. (2004) DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 279: 15269-15273.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

H Takai, K Naka, M Watanabe, Y Okada, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.  EMBO J  21: 5195-5205

K Kobayashi, M Watanabe, Y Okada, H Takai, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Hydrocephalus and male infertility in DNA polymerase alpha-deficient mice. Mol Cell Biol 22: 2769-2776

T Sasaki, S Kamimura, H Takai, A Watanabe, K Onitake (2002) The activity for the induction of the sperm acrosome reaction localizes in the outer layers and exists in the high-molecular-weight components of the egg-jelly of the newt, Cynops pyrrhogaster. Zygote 10: 1-9

H Takai, K Tominaga, N Motoyama, YA Minamishima, H Nagahama, T Tsukiyama, K Ikeda, K Nakayama, M Nakanishi, K Nakayma K. (2000) Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice. Genes Dev 14: 1439-1447

M Kanematsu, T Sato, H Takai, K Watanabe, K Ikeda, Y Yamada. (2000) PGE2 induces expression of RANKL on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency.  J Bone Miner Res 15: 1321-1329

K Onitake, H Takai, M Ukita, JI Mizuno, T Sasaki, A Watanabe. (2000) Significance of egg-jelly substances in the internal fertilization of the newt, Cynops pyrrhogaster. Comp Biochem Physiol B Biochem Mol Biol 126: 121-128

H Mohri, K Inaba, M Kubo-Irie, H Takai, Y Yano-Toyoshima. (1999) Characterization of outer arm dynein in sea anemone, Anthopleira midori. Cell Motil Cytoskeleton 44: 202-208

H Takai, M Kanematsu, K Yano, E Tsuda, K Higashio, K Ikeda, K Watanabe, Y Yamada. (1998) TGF-β stimulates the production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by bone marrow stromal cells.  J Biol Chem 273: 27091-27096

M Kanematsu, H Takai, Y Yamada. (1998) Actions of nitric oxide in the regulation of osteoclasts and osteoblasts. Curr Opinion Orthopedics 9: 11-16

Y Yamada, A Miyauti, J Goto, Y Takagi, H Okuizumi, M Kanematsu, M Hase, H Takai, A Harada, K Ikeda. (1998) Association of a polymorphism of the Transforming Growth Factor β-1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13: 1569-1576

T Kameda, H Mano, Y Yamada, H Takai, N Amizuka, M Kobori, N Izumi, H Kawasima, H Ozawa, K Ikeda, A Kameda, Y Hakeda, M Kumegawa (1998) Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells.  Biochem Biophys Res Commun 245: 419-422.

K Ogawa, H Takai, A Ogiwara, E Yokota, T ShimizuT, K Inaba, H Mohri. (1996) Is outer arm dynein intermediate chain 1 multifunctional? Mol Biol Cell 7: 1895-1907

H Shimizu, T Majima, H Takai, K Inaba, T Tomie (1995) Morphological changes of wrasse sperm axoneme after their motility initiation observed with use of atomic force microscopy. SPIE 2384: 45-51.

H Takai and M Morisawa (1995) Change in intracellular K+ concentration caused by external osmolality change regulates sperm motility of marine and freshwater teleosts.  J Cell Sci 108: 1175-1181

 

Graduate Students Zachary Mirmany Publications:

Leonid Timashev Publications:

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalScience 327: 1657-1661.

BQ Vuong, M Lee, S Kabir, C Irimia, S Macchiarulo, GS McKnight, J Chaudhuri (2009) Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10: 420-426

 

 

Zhe Yang's Publications:

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. in press

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalScience 327: 1657-1661.

BQ Vuong, M Lee, S Kabir, C Irimia, S Macchiarulo, GS McKnight, J Chaudhuri (2009) Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10: 420-426

 

 

 

 

Zhe Yang Publications:

K.K. Lim, T.Y. Ong, Y.R. Tan, E.G. Yang, B. Ren, K.S. Seah, Z. Yang, T.S. Tan, B.W. Dymock & E.S. Chen (2015.) Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Sci Rep 5: 14064

  

Research Assistants

Kaori Takai Publications:
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. Chem. 285: 1457-1467.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.

E Itakura, K Takai, K Umeda, M Kimura, M Ohsumi, K Tamai, and A Matsuura, (2004) Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett 577: 289-293

C Kitazawa, K Takai, Y Nakajima, H Fujisawa, S Amemiya, (2004) LiCl inhibits the establishment of left-right asymmetry in larvae of the direct-developing echinoid Peronella japonica. J Exp Zool A Comp Exp Biol FEBS Lett Cell Struct Funct Hepatology 301: 707-17

K Takai, S Hattori, and S Irie, (2001) Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct 26: 289-302

C Tateno, K Takai-Kajihara, C Yamasaki, H Sato, and K Yoshizato, (2000) Heterogeneity of growth potential of adult rat hepatocytes in vitro. Hepatology 31: 65-74

 

Postdoctoral Fellows and Associates Nazario Bosco Publications:N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosom