Current Member Publications

Postdoctoral Fellows and Associates

 

Nazario Bosco Publications:

N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465

Pelliccia F*, Bosco N*, Rocchi A (2010) Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 - Molecular characterization of FRA2H and localization of a new CFS FRA2S. Cancer Lett, 299(1): 37-44. (*co-first authors)

Bosco N, Pelliccia F, Rocchi A (2010) Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region. Cancer Genet Cytogenet, 202(1): 47-52.

Pelliccia F, Bosco N, Curatolo A, Rocchi A (2008) Replication timing of two human common fragile sites: FRA1H and FRA2G. Cytogenet Genome Res, 121(3-4):196-200.

Pelliccia F, Curatolo A, Limongi MZ, Bosco N, Rocchi A (2007) Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. Cancer Genetics and Cytogenetics,178: 144-150.Sally Dewhurst Publications:

R.A. Burrell, S.E. Mcclelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, S.K. Chew, A.J. Rowan, A. Schenk, M. Sheffer, M. Howell, M. Kschischo, A. Behrens, T. Helleday, J. Bartek, I.P. Tomlinson & C. Swanton (2013.) Replication stress links structural and numerical cancer chromosomal instability. Nature 494: 492-496.

Dewhurst & C. Swanton (2015.) Tetraploidy and CIN: a dangerous combination. Cell Cycle 14: 3217.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

Gerlinger, N. Mcgranahan, S.M. Dewhurst, R.A. Burrell, I. Tomlinson & C. Swanton (2014.) Cancer: evolution within a lifetime. Annu Rev Genet 48: 215-236.

 

 

Sally Dewhurst Publications:

A. Crockford, L.P. Zalmas, E. Grönroos, S.M. Dewhurst, N. Mcgranahan, M.E. Cuomo, V. Encheva, A.P. Snijders, J. Begum, S. Purewal, J. Cerveira, H. Patel, M.J. Renshaw & C. Swanton (2017.) Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. Ann Oncol 28: 149-156.

L. Sansregret, J.O. Patterson, S. Dewhurst, C. López-García, A. Koch, N. Mcgranahan, W.C. Chao, D.J. Barry, A. Rowan, R. Instrell, S. Horswell, M. Way, M. Howell, M.R. Singleton, R.H. Medema, P. Nurse, M. Petronczki & C. Swanton (2017.) APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discov 7: 218-233.

S. Dewhurst & C. Swanton (2015.) Tetraploidy and CIN: a dangerous combination. Cell Cycle 14: 3217.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

M. Gerlinger, N. Mcgranahan, S.M. Dewhurst, R.A. Burrell, I. Tomlinson & C. Swanton (2014.) Cancer: evolution within a lifetime. Annu Rev Genet 48: 215-236.

S.M. Dewhurst, N. Mcgranahan, R.A. Burrell, A.J. Rowan, E. Grönroos, D. Endesfelder, T. Joshi, D. Mouradov, P. Gibbs, R.L. Ward, N.J. Hawkins, Z. Szallasi, O.M. Sieber & C. Swanton (2014.) Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov 4: 175-185.

R.A. Burrell, S.E. Mcclelland, D. Endesfelder, P. Groth, M.C. Weller, N. Shaikh, E. Domingo, N. Kanu, S.M. Dewhurst, E. Gronroos, S.K. Chew, A.J. Rowan, A. Schenk, M. Sheffer, M. Howell, M. Kschischo, A. Behrens, T. Helleday, J. Bartek, I.P. Tomlinson & C. Swanton (2013.) Replication stress links structural and numerical cancer chromosomal instability. Nature 494: 492-496.

 

 

Yi Gong Publications:

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.

Y Gong, JN Lee, PC Lee, Jl Goldstein, MS Brown, J Ye (2006) Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism 3:15-24.

Y Gong, JN Lee, MS Brown, Jl Goldstein, J Ye (2006) Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Nat Acad Sci 103: 6154-6159.

JN Lee, Y Gong, X Zhang, J Ye (2006) Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Nat Acad Sci 103: 4958-4963.

T Yang, PJ Espenshade, ME Wright, D Yabe, Y Gong, R Aebersold, Jl Goldstein, MS Brown (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110: 489-500.

G Zhou, H Li, Y Gong, Y Zhao, J Cheng, P Lee, Y Zhao (2005) Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. Proteomics 5: 3814-3821.

G Zhou, H Li, D DeCamp, S Chen, H Shu, Y Gong, M Flaig, JW Gillespie, N Hu, PR Taylor, LA Liotta, MR Emmert-Buck, EF Petricoin III, Y Zhao (2002) 2D differential in-gel electrophoresis for the identification of esophageal squamous cell cancer-specific protein markers. Mol Cell Proteomics 1: 117-124.

DW Yu, T Yang, T Sonoda, Y Gong, Q Cao, K Gaffney, PJ Jensen, IM Freedberg, RM Lavker, TT Sun (2001) Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. J Invest Dermatology 117: 1554-1558.

Y Gong, KD Liu, G Zhou, Q Xie, SL Chen, ZY Tang (1998) Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft. World J Gastroenterology 4: 7-9.

 

 

Francisca Alessandra Lottersberger Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA, 110: 2146-2151. **equal contribution. *corresponding author.

F Lottersberger , A Panza, G Lucchini, MP Longhese (2007) Functional and physical interactions between yeast 14-3-3, acetyltransferase and deacetylase proteins in response to DNA replication stress. Mol Cell Biol 27: 3266-3281.

F Lottersberger , A Panza, S Piatti, G Lucchini, MP Longhese (2006) The Saccharomyces cerevisiae 14-3-3 Proteins Are Required for the G1/S Transition, Actin Cytoskeleton Organization and Cell Wall Integrity. Genetics 173 : 661-675.

M Clerici, V Baldo, D Mantiero, F Lottersberger , G Lucchini, MP Longhese (2004) A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol 24: 10126-10144.

F Lottersberger , F Rubert, V Baldo, G Lucchini, and MP Longhese (2003) Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress. Genetics 165 :1717-1732.

 

 

Courtney Lovejoy Publications:
C.A. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Petrini, P.A. Sung, M. Jasin, J. Rosenbluh, Y. Zwang, B.A. Weir, C. Hatton, E. Ivanova, L. Macconaill, M. Hanna, W.C. Hahn, N.F. Lue, R.R. Reddel, Y. Jiao, K. Kinzler, B. Vogelstein, N. Papadopoulos, A.K. Meeker. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772 * corresponding author.

T Wiltshire, CA Lovejoy, T Wang, F Xia, MJ O'Connor, and D Cortez, (2010) Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem 285: 14565-14571

CA Lovejoy, X Xu, CE Bansbach, GG Glick, R Zhao, F Ye, BM Sirbu, LC Titus, Y Shyr, D Cortez (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc Nat Acad Sci 106: 19304-19309.

CE Bansbach, R Betous, CA Lovejoy, GG Glick, D Cortez (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev 23: 2405-2414.

CA Lovejoy, D Cortez (2009) Common mechanisms of PIKK regulation. DNA Repair (Amst) 8: 1004-1008.

CA Lovejoy, K Lock, A Yenamandra, D Cortez (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 21: 7977-90.

AJ Danielsen, TA Christensen, CA Lovejoy, MA Adelsman, DC Connolly, NJ Maihle (2004) Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation. Exp Cell Res 2: 285-293.

JL Boerner, AJ Danielsen, CA Lovejoy, Z Wang, SC Juneja, JM Faupel-Badger, JR Darce, NJ Maihle (2003) Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22: 6679-6689.

 

 

John Maciejowski Publications:

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. in press

J. Maciejowski & T. de Lange (2017) Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol 18: 175-186.

J. Maciejowski, Y. Li, N. Bosco, P.J. Campbell & T. de Lange (2015) Chromothripsis and Kataegis Induced by Telomere Crisis. Cell 163: 1641-1654.

Rodriguez-Bravo, J. Maciejowski, J. Corona, H.K. Buch, P. Collin, M.T. Kanemaki, J.V. Shah, and P.V. Jallepalli (2014). Nuclear pores protect genome integrity by assembling a premitotic and mad1-dependent anaphase inhibitor. Cell 156: 1017-1031.

Randall-Paschal C, Maciejowski J, Jallepalli PV. (2012) A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma 121: 565-572

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV (2010)  Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 190: 89-100

McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJ (2009) A “latent niche” mechanism for tumor initiation. Proc Natl Acad Sci USA. 106: 11617-22

Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7: e10000111

Maciejowski J, Ugel N, Mishra B, Isopi M, Hubbard EJ (2006) Quantitative analysis of germline mitosis in adult C. elegans. Dev Biol. 292: 142-51

Maciejowski J, Ahn JH, Cipriani PG, Killian DJ, Chaudhary AL, Lee JI, Voutev R, Johnsen RC, Baillie DL, Gunsalus KC, Fitch DH, Hubbard EJ (2005) Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics 169: 1997-2011
 
 

Nanda Sasi Publications:

N.K. Sasi, A. Bhutkar, N.J. Lanning, J.P. Mackeigan & M. Weinreich (2017.) DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia 19: 439-450.

N.K. Sasi, K. Tiwari, F.F. Soon, D. Bonte, T. Wang, K. Melcher, H.E. Xu & M. Weinreich (2014.) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One 9: e113300.

L. Woodbine, J.A. Neal, N.K. Sasi, M. Shimada, K. Deem, H. Coleman, W.B. Dobyns, T. Ogi, K. Meek, E.G. Davies & P.A. Jeggo (2013.) PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest 123: 2969-2980.

 

Isabelle Schmutz Publications:

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

I. Schmutz & T. de Lange (2016) Shelterin. Curr Biol. 26: R397.

I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev 24(4): 345-357. PMCID: PMC2816734

F. Stadler, I. Schmutz, B. Schwaller, and U. Albrecht (2010) Lack of calbindin-D28K alters response of the murine circadian clock to light. Chronobiol. Int, 27(1): 68-82

M. Darna, I. Schmutz, K. Richter, S.V. Yelamanchili, G. Pendyala, M. Holtje, U. Albrecht, G. Ahnert-Hilger (2009) Time of Day-dependent Sorting of the Vesicular Glutamate Transporter to the Plasma Membrane. J Biol Chem 284: 4300-4307

G. Hampp, J.A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perreau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J.H. Meijer, U. Albrecht (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol 18: 678-683

MA Farre-Castany, B Schwaller, P Gregory, J Barski, C Mariethoz, JL Eriksson, IV Tetko. D Wolfer, MR Celio, I Schmutz, U Albrecht, AE Villa (2007) Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbulin, calbindin D-28k or both. Behav Brain Res 178: 250-261

C Jud, I Schmutz, G Hampp, H Oster, U Albrecht (2005) A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions. Biol Proced Online 7: 101-116

 

Hiro Takai Publications:

E.A. Ahmed, A. Sfeir, H. Takai, and H. Scherthan (2013). Ku70 and non-homologous end joining protect testicular cells from DNA damage. J Cell Sci 126: 3095-3104.

P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

Z. Horejsi, H. Takai, S. Collins, H. Flynn, S. Maslen, J.M. Skehel, T. de Lange, and S. Boulton (2010) CK2 phospho-dependent binding of R2TP complex to Tel2 is essential for mTOR and SMG1 stability. Mol. Cell, 39:839-850.

H. Takai, Y. Xiey*, T. de Lange** and N.P. Pavletich** (2010) Tel2 is a helical repeat protein that mediates Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24: 2019-2030.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

L Cao, S Kim, C Xiao, R Wang, X Coumoul, X Wang, WM Li, X XuL, JA De Soto, H Takai, S Mai, SJ Elledge, N Motoyama, CX Deng. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 25: 2167-77.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

MT Jack, RA Woo, N Motoyama, H Takai, Lee PW. (2004) DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 279: 15269-15273.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

H Takai, K Naka, M Watanabe, Y Okada, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.  EMBO J  21: 5195-5205

K Kobayashi, M Watanabe, Y Okada, H Takai, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Hydrocephalus and male infertility in DNA polymerase alpha-deficient mice. Mol Cell Biol 22: 2769-2776

T Sasaki, S Kamimura, H Takai, A Watanabe, K Onitake (2002) The activity for the induction of the sperm acrosome reaction localizes in the outer layers and exists in the high-molecular-weight components of the egg-jelly of the newt, Cynops pyrrhogaster. Zygote 10: 1-9

H Takai, K Tominaga, N Motoyama, YA Minamishima, H Nagahama, T Tsukiyama, K Ikeda, K Nakayama, M Nakanishi, K Nakayma K. (2000) Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice. Genes Dev 14: 1439-1447

M Kanematsu, T Sato, H Takai, K Watanabe, K Ikeda, Y Yamada. (2000) PGE2 induces expression of RANKL on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency.  J Bone Miner Res 15: 1321-1329

K Onitake, H Takai, M Ukita, JI Mizuno, T Sasaki, A Watanabe. (2000) Significance of egg-jelly substances in the internal fertilization of the newt, Cynops pyrrhogaster. Comp Biochem Physiol B Biochem Mol Biol 126: 121-128

H Mohri, K Inaba, M Kubo-Irie, H Takai, Y Yano-Toyoshima. (1999) Characterization of outer arm dynein in sea anemone, Anthopleira midori. Cell Motil Cytoskeleton 44: 202-208

H Takai, M Kanematsu, K Yano, E Tsuda, K Higashio, K Ikeda, K Watanabe, Y Yamada. (1998) TGF-β stimulates the production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by bone marrow stromal cells.  J Biol Chem 273: 27091-27096

M Kanematsu, H Takai, Y Yamada. (1998) Actions of nitric oxide in the regulation of osteoclasts and osteoblasts. Curr Opinion Orthopedics 9: 11-16

Y Yamada, A Miyauti, J Goto, Y Takagi, H Okuizumi, M Kanematsu, M Hase, H Takai, A Harada, K Ikeda. (1998) Association of a polymorphism of the Transforming Growth Factor β-1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13: 1569-1576

T Kameda, H Mano, Y Yamada, H Takai, N Amizuka, M Kobori, N Izumi, H Kawasima, H Ozawa, K Ikeda, A Kameda, Y Hakeda, M Kumegawa (1998) Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells.  Biochem Biophys Res Commun 245: 419-422.

K Ogawa, H Takai, A Ogiwara, E Yokota, T ShimizuT, K Inaba, H Mohri. (1996) Is outer arm dynein intermediate chain 1 multifunctional? Mol Biol Cell 7: 1895-1907

H Shimizu, T Majima, H Takai, K Inaba, T Tomie (1995) Morphological changes of wrasse sperm axoneme after their motility initiation observed with use of atomic force microscopy. SPIE 2384: 45-51.

H Takai and M Morisawa (1995) Change in intracellular K+ concentration caused by external osmolality change regulates sperm motility of marine and freshwater teleosts.  J Cell Sci 108: 1175-1181

 

Graduate Students Zachary Mirmany Publications:

 

Zachary Mirman Publications:

A.C. Paré, A. Vichas, C.T. Fincher, Z. Mirman, D.L. Farrell, A. Mainieri & J.A. Zallen (2014) A positional Toll receptor code directs convergent extension in Drosophila. Nature 515: 523-527.

 

Leonid Timashev Publications:

I. Schmutz, L. Timashev, W. Xie, D.J. Patel & T. de Lange (2017) TRF2 binds branched DNA to safeguard telomere integrityNat. Struct. Mol. Biol. ePub ahead of print

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signalScience 327: 1657-1661.

BQ Vuong, M Lee, S Kabir, C Irimia, S Macchiarulo, GS McKnight, J Chaudhuri (2009) Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10: 420-426

 

Zhe Yang's Publications:

Z. Yang, J. Maciejowski & T. de Lange (2017) Nuclear envelope rupture is enhanced by loss of p53 or Rb. Mol. Cancer Res. in press

K.K. Lim, T.Y. Ong, Y.R. Tan, E.G. Yang, B. Ren, K.S. Seah, Z. Yang, T.S. Tan, B.W. Dymock & E.S. Chen (2015.) Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Sci Rep 5: 14064

  

Research Assistants

Kaori Takai Publications:
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. Chem. 285: 1457-1467.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.

E Itakura, K Takai, K Umeda, M Kimura, M Ohsumi, K Tamai, and A Matsuura, (2004) Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett 577: 289-293

C Kitazawa, K Takai, Y Nakajima, H Fujisawa, S Amemiya, (2004) LiCl inhibits the establishment of left-right asymmetry in larvae of the direct-developing echinoid Peronella japonica. J Exp Zool A Comp Exp Biol FEBS Lett Cell Struct Funct Hepatology 301: 707-17

K Takai, S Hattori, and S Irie, (2001) Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct 26: 289-302

C Tateno, K Takai-Kajihara, C Yamasaki, H Sato, and K Yoshizato, (2000) Heterogeneity of growth potential of adult rat hepatocytes in vitro. Hepatology 31: 65-74

 

Postdoctoral Fellows and Associates Nazario Bosco Publications:N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosom